Human Sera
Cayman Chemical MondnsylcadaverIn 100mg
Differs from MAM2201 by having chlorine rather than fluorine on the terminal carbon of the alkyl group intended for forensic and research applications
Cayman Chemical PaltusotIn 50mg
A peptide substrate for Akt corresponds to the amino acid sequence of GSK3 that surrounds the serine residue phosphorylated by RSK1 or p70S6K also a substrate for SGK3
Cayman Chemical RobenacoxIb 100mg
A peptide inhibitor of NTMT1 (IC50 0.054 UM) binds to NTMT1 and NTMT2 (Kds 0.3 and 1 UM respectively) and inhibits N-terminal dimethylation of RCC1 by NTMT1 in a cell-free assay at 10 and 50 UM reduces trimethylation of the RCC1 SPKRIA motif in HCT116 cells at 100 UM
Cayman Chemical MItoBloCK-10 50mg
A fluorogenic substrate for SARS-CoV Mpro Mca is released upon cleavage by SARS-CoV Mpro and its fluorescence can be used to quantify SARS-CoV Mpro activity ex/em 328/420 nm respectively
Cayman Chemical DebrIsoquInhemIsulfate 50mg
An anticonvulsant inhibits tonic convulsions induced by pentylenetetrazole and MES in mice (ED50s 78 1 and 103 mg/kg respectively)
Cayman Chemical MesorIdazIn 50mg
A multi-kinase inhibitor (IC50s 0 3 16 1 5 8 7 and 1 4 nM for EGFR ErbB2 KDR FLT4 and EphB4 respectively) selective for these kinases over a panel of 10 tyrosine kinases and 55 serine/threonine kinases at 10 M inhibits growth of A431 cells expressing wild-type EGFR and H1975 NSCLC cells expressing both EGFRL858R and EGFRT790M (IC50s 13 and 920 nM respectively) inhibits tumor growth and EGFR phosphorylation in an H1975 mouse xenograft model at 10 30 and 100 mg/kg
Cayman Chemical D-LysIn lactam 100mg
A building block in the synthesis of a variety of compounds with industrial applications including acrylic acid acrylamide and 13-propanediol accumulation is used as a biomarker of defects in propionic acid and branched-chain amino acid catabolism in patients with methylmalonic acidemia or propionic acidemia
Cayman Chemical Cefmetazole 100mg
An endogenous peptide fragment of ACTH an agonist of MC3R and MC4R (EC50s 23 and 330 nM respectively) increases mean arterial pressure (ED50 287 nmol/kg) and heart rate (ED50 313 nmol/kg) in rats also improves aortic and coronary blood flow and left ventricular developed pressure following cardiac ischemia and reperfusion at 200 Ug/kg in rats accelerates motor function improvements in a rat model of sciatic nerve crush at 10 Ug per animal
Cayman Chemical SNBocLHomoserIn ethyl 50mg
An actin-sequestering peptide regulates cytoskeletal rearrangement by binding to actin (Kds 0 7 and 2 1 UM for human platelets and rabbit muscle respectively) and inhibiting the polymerization of actin monomers increases in vitro migration of HUVECs keratinocytes and coronary artery endothelial cells but not fibroblasts actin smooth muscle cells neutrophils monocytes or HT-1080 fibrosarcoma cells at 0 001-1 Ug/ml increases gap closure and reduces wound width in a rat full-thickness cutaneous wound model at 60 Ug inhibits TNF-a induced NF- B phosphorylation and nuclear translocation in immortalized human corneal epithelial cells at 1 Ug/ml decreases the expression of CXCL1 CXCL2 MMP-9 and MMP-2 in the cornea in a mouse model of sodium hydroxide-induced corneal injury at 5 Ug
Cayman Chemical GC376sodIum salt 100mg
A degradation product of oxytetracycline has been found in swine manure compost and wastewater considered a pollutant
Cayman Chemical GluCys ammonium salt 100mg
An internal standard for the quantification of bezafibrate by GC- or LC-MS
Cayman Chemical ClothInIdIn 100mg
A peptide agonist of PAR4 activates PAR4 and the cleavage site mutant PAR4R47A at 500 UM induces platelet aggregation of isolated washed human platelets at 1 mM but does not affect clotting time ex vivo
Cayman Chemical ML-133hydrochlorIde 50mg
A peripherally selective androgen receptor antagonist binds to AR and inhibits AR-regulated transcription in a reporter cell line in vitro inhibits androgen-regulated lipid synthesis in primary human sebocytes inhibits inflammatory cytokine production from primary human sebocytes and scalp dermal papilla cells inhibits testosterone propionate-induced flank organ enlargement in Syrian golden hamsters by 84 when administered topically at 400 g/animal